研究方向： 

纳米药物的设计合成、结构优化和功能测定及其临床应用中的生物机制

获奖及荣誉： 

2016年度中科院-沙特基础工业公司（SABIC-CAS）导师科研奖

2015年度国家纳米科学中心科研卓越奖

2015年获得中国科学院-BHHB（必和必拓）导师科研奖

2014年获得河北省自然科学进步奖二等奖

2014年获得国家质量监督检验检疫总局“科技兴检奖”

2012年获得中国药学会青年药剂学家奖

2010年国务院政府特殊津贴获得者 

2004、2005、2006连续三年获得NIH优秀科研奖

天津大学 兼职教授 

中国医学科学院生物医学工程研究所 兼职教授

代表论著： 

2015年 

1.Wei T, Chen C, Liu J, Liu C, Posocco P, Liu X, Cheng Q, Huo S, Liang Z, Fermeglia M, Pricl S, Liang XJ*, Rocchi P, Peng L*. Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance. Proc Natl Acad Sci U S A. 2015. 112(10):2978-83. 　  

2.Han S, Cheng Q, Wu Y, Zhou J, Long X, Wei T, Huang Y, Zheng S, Zhang J, Deng L, Wang X, Liang XJ, Cao H, Liang Z, Dong A. Effects of hydrophobic core components in amphiphilic PDMAEMA nanoparticles on siRNA delivery. Biomaterials. 2015. 48:45-55. 

3. Xue X, Jin S, Zhang C, Yang K, Huo S, Chen F, Zou G, Liang XJ*. Probe-inspired nano-prodrug with dual-color fluorogenic property reveals spatiotemporal drug release in living cells. ACS Nano. 2015. 9(3):2729-39. 　　  

4.Zhang C, Li Y, Xue X, Chu P, Liu C, Yang K, Jiang Y, Chen WQ, Zou G, Liang XJ*. A smart pH-switchable luminescent hydrogel. Chem Commun. 2015. 51(20):4168-71. (Cover) 　　  

5.Zhang J, Li C, Zhang X, Huo S, Jin S, An FF, Wang X, Xue X, Okeke CI, Duan G, Guo F, Zhang X, Hao J, Wang PC, Zhang J, Liang XJ*. In vivo tumor-targeted dual-modal fluorescence/CT imaging using a nanoprobe co-loaded with an aggregation-induced emission dye and gold nanoparticles. Biomaterials. 2015. 42:103-11. 

2014年 

1.Shengliang Li, Kelei Hu, Weipeng Cao, Yun Sun, Wang Sheng, Feng Li, Yan Wu, Xing-Jie Liang*. pH-Responsive Biocompatible Fluorescent Polymer Nanoparticles Based on Phenylboronic Acid for Intracellular Imaging and Drug Delivery. Nanoscale 2014. 6(22):13701-9.

2. Xue X, Wang L, Sato Y, Jiang Y, Berg M, Yang DS, Nixon R, Liang XJ*.  Single-walled carbon nanotubes alleviate autophagic/lysosomal defects in primary glia from a mouse model of Alzheimer's disease. Nano Lett. 2014. 14(9):5110-7

3. Lu Han, Yu-Xia Zhao, Cheng-Mei Liu, Lu-Hai Li, Xing-Jie Liang, Yen Wei.The effects of nanoparticle shape on electrical conductivity of Ag nanomaterials. J Mater Sci. 2014. DOI 10.1007/s10854-014-2101-1 

4. Xu Zhang, YuanYuan Zhao, Yi Xu, Yuanming Pan, Chen Fei, Anil Kumar, Guozhang Zou and Xing-Jie Liang*. In Situ Self-Assembly of Peptides in Glucan Particles for Macrophage-Targeted Oral Delivery. Journal of Material Chemistry B. 2014. 2. 5882-5890. 

5. Liu H, Li Y, Mozhi A, Zhang L, Liu Y, Xu X, Xing J, Liang XJ, Ma G, Yang J, Zhang X. SiRNA-phospholipid conjugates for gene and drug delivery in cancer treatment. Biomaterials. 2014. 35(24):6519-6533.

6. Xing-Jie Liang. Nanotechnology and Cancer Nanomedicine. Biotechnology Advances 2014.32(4): 665. (Editorial comments)

7. 梁兴杰和孔德领。纳米药物的现状和展望。《中国医学科技发展报告》 2013. Page 100-103.

8. Shuaidong Huo, Shubin Jin, Xiaowei Ma, Xiangdong Xue, Keni Yang, Paul C. Wang, Jinchao Zhang, Zhongbo Hu, and Xing-Jie Liang*. Ultra-small Gold Nanoparticles as Carriers for Nucleus-based Gene Therapy Due to Size-dependent Nuclear Entry. ACS nano. 2014. 24; 8(6): 5852-5862.  

9. Shubin Jin, Shengliang Li, Chongxi Wang, Juan Liu, Xiaolong Yang, Paul C. Wang, Xin Zhang, and Xing-Jie Liang*. Biosafe Nanoscale Pharmaceutical Adjuvant Materials. Journal of Biomedical Nanotechnology. 2014. 10: 2393-2419.

10. Li-Rong Wang, Xue Xue, Xiao-Mei Hu, Ming-Yuan Wei, Guang-Lu Ge,* and Xing-Jie Liang*. Structure-dependent Mitochondrial Dysfunction and Hypoxia Induced with Single-walled Carbon Nanotubes. Small. 2014. 10(14): 2859-2869.

11. Chunqiu Zhang, Shubin Jin, Shengliang Li, Xiangdong Xue, Juan Liu, Yuran Huang, Yonggang Jiang, Wei-Qiang Chen, Guozhang Zou* and Xing-Jie Liang*. Imaging Intracellular Anti-Cancer Drug Delivery by Self-Assembly Micelles with Aggregation-Induced Emission (AIE Micelles). ACS Applied Materials & Interfaces. 2014. 9;6(7):5212-5220. 

12. Yuran Huang, Tuo Wei, Jing Yu, Yanglong Hou, Kaiyong Cai*, Xing-Jie Liang*. Multifunctional metal rattle-type nanocarriers for MRI-guided photothermal cancer therapy. Molecular Pharmaceutics 2014. 11(10):3386-94.

13. Kumar A.; Huo S.; Zhang X.; Liu J.; Tan A.; Li S.; Jin S.; Xue X.; Zhao Y.; Han L.; Liu H.; Zhang X.; Zhang J.; Zou G.; Wang T.; Tang S.; Liang XJ. Neuropilin-1-targeted Gold Nanoparticles Enhance Therapeutic Efficacy of platinum(IV) Drug for Prostate Cancer Treatment. ACS nano. 2014. 27:8(5): 4205-4220.

14. Feifei An, Weipeng Cao and Xing-Jie Liang*. Nanostructural Systems Developed with Positive Charge Generation to Drug Delivery. Advanced Healthcare Materials. 2014. 3(8): 1162-1181.

15. Li S.; Cao W.; Jin S.; Kumar A.; Liu J.; Zhang C.; Zou G.;Li F.; Liang XJ. Near-Infrared Fluorescent Aptamer-templated Silver Nanoclusters Facile Synthesized for Cellular Imaging Applications. China.Sci.Bull. 2014. 59(16):1668-1872. 

16. Juan Liu, Yuran Huang, Anil Kumar, Aaron Tan, Shubin Jin, Anbu Mozhi, Xing-Jie Liang*. pH-Sensitive nano-systems for drug delivery in cancer therapy. Biotechnology Advances 2014.32(4): 693-710.

17. Mahmoudi M, Meng J, Xue X, Liang XJ, Rahman M, Pfeiffer C, Hartmann R, Gil PR, Pelaz B, Parak WJ, Del Pino P, Carregal-Romero S, Kanaras AG, Tamil Selvan S. Interaction of stable colloidal nanoparticles with cellular membranes. Biotechnology Advances. 2014. 32(4):679-692.

18. Keni Yang, Chunqiu Zhang, Wei Wang, Paul C. Wang, Jianping Zhou,*, Xing-Jie Liang*. pH-Responsive Mesoporous Silica Nanoparticles applied in Controlled Drug Delivery Systems for Cancer Treatment. Cancer Biology and Medicine. 2014. 11(1):34-43. 

19. Shengliang Li, Weipeng Cao, Anil Kumar, Shubin Jin, Yuanyuan Zhao, Chunqiu Zhang, Guozhang Zou, Paul C. Wang, Feng Li, and Xing-Jie Liang*. Highly Sensitive Simultaneous Detection of Mercury and Copper Ions by Ultrasmall Fluorescent DNA-Ag Nanoclusters. New Journal of Chemistry. 2014, 38 (4), 1546 – 1550. 

20. Carrion C, Nazarenus M, Paradinas S, Romero S, Almendral M, Fuentes M, Pelaz B, del Pino P, Hussain I, Clift M, Rutishauser B, Liang XJ and Parak W. Metal ions in the context of nanoparticles toward biological applications. Current Opinion in Chemical Engineering. 2014. 4:88-96. 

21. Xiangdong Xue, Yuanyuan Zhao, Luru Dai, Xu Zhang, Xiaohong Hao, Shuaidong Huo, Juan Liu, Chang Liu, Anil Kumar, Weiqing Chen, Guozhang Zou,* Xing-Jie Liang*. Spatiotemporal Drug Release Visualized Through a Drug Delivery System with Tunable Aggregation-Induced Emission. Advanced Materials. 2014. 26(5):712-717. （Article highlighted by "Noteworthy Chemistry", a news weekly published electronically by the American Chemical Society (ACS). December 16, 2013. ） 

22. Fei-Fei An, Yin-Long Yang, Juan Liu, Jun Ye, Jin-Feng Zhang, Meng-Jiao Zhou, Xiu-Juan Zhang,* Cai-Jun Zheng, Xing-Jie Liang, Xiao-Hong Zhang,* Reticuloendothelial System-Stealthy Dye-Albumin Nanocomplex as a Highly Biocompatible and Highly Luminescent Nanoprobe for Targeted In Vivo Tumor Imaging. RSC Advances. 2014. 4: 6120-6126.

23. Xiaolong Xu, Yuanyuan Zhao, Xiangdong Xue, Shuaidong Huo, Fei Chen, Guozhang Zou* and Xing-Jie Liang*. Seedless Synthesis of High Aspect Ratio Gold Nanorods with High Yield. Journal of Materials Chemistry A. 2014. 2: 3528-3535. 

24. Han L.; Zhao J.; Liu J.; Duan X.; Wei Y.; Liang XJ. A universal gene carrier platform for treatment of human prostatic carcinoma by p53 transfection. Biomaterials. 2014 35(9):3110-3120. 

25. JunYa Peng, Ran Zhang, YiTong Cui, HaoDong Liu, XiaoXin Zhao, Lei Huang, MingXu Hu, XiaoXi Yuan, BenYu Ma, XiaoWei Ma, Ueno Takashi, Komatsu Masaaki, Xing-Jie Liang, Li Yu*. Atg5 regulates late endosome and lysosome biogenesis. Science in China (Life Sciences) 2014, 57: 59-68. 

26. Yan Li, Qiang Cheng, Qian Jiang, Yuanyu Huang, Hongmei Liu, Yuliang Zhao, Weipeng Cao, Guanghui Ma, Fengying Dai, Xing-Jie Liang*, Zicai Liang, Xin Zhang*. Enhanced endosomal/lysosomal escape by distearoyl phosphoethanolamine - polycarboxybetaine lipid for systemic delivery of siRNA. Journal of Controlled Release.   2014,176: 28:104–114. 

27. Chunqiu Zhang, Chang Liu, Xiangdong Xue, Shuaidong Huo, Yonggang Jiang, Wei-Qiang Chen, Guozhang Zou* and Xing-Jie Liang*. Salt-Responsive Self-Assembly of Luminescent Hydrogel with Intrinsic Gelation-Enhanced Emission. ACS Applied Materials & Interfaces. 2014. Jan 22;6(2):757-762. （Article highlighted by "Noteworthy Chemistry", a news weekly published electronically by the American Chemical Society (ACS). February 24, 2014. http://www.acs.org/content/acs/en/noteworthy-chemistry/2014-archive/february-24.html#nc5 ） 

28. Zhang XD, Chen J, Luo Z, Wu D, Shen X, Song SS, Sun YM, Liu PX, Zhao J, Huo S, Fan S, Fan F, Liang XJ*, Xie J. Enhanced Tumor Accumulation of Sub-2 nm Gold Nanoclusters for Cancer Radiation Therapy. Adv Health Mater. 2014. 3 (1): 133-141. (Back cover) 

29. Liming Hu, Yun Sun, Shengliang Li, Xiaoli Wang, Kelei Hu, Lirong Wang, Xing-jie Liang, Yan Wu. Multifunctional carbon dots with high quantum yield for imaging and gene delivery. Carbon. 2014. 67: 508–513. 　

30.  Chunqiu Zhang, Shubin Jin, Keni Yang, Xiangdong Xue, Zhipeng Li, Yonggang Jiang,Wei-Qiang Chen, Luru Dai, Guozhang Zou,*and Xing-Jie Liang*. Cell Membrane Tracker Based on Restriction of Intramolecular Rotation. ACS Applied Materials & Interfaces. 2014. 6(12):8971-8975. 

31. Zhang C, Xue X, Luo Q, Li Y, Yang K, Zhuang X, Jiang Y, Zhang J, Liu J, Zou G, Liang XJ*. Self-assembled Peptede nanofibers designed as biological enzymes for catalyzing ester hydrolysis. ACS Nano. 2014. 8(11): 11715-23.

2013年 

1. Tuo Wei, Juan Liu, Huili Ma, Qiang Cheng, Yuanyu Huang, Jing Zhao, Shuaidong Huo, Xiangdong Xue, Zicai Liang, Xingjie Liang. Functionalized Nanoscale Micelles Improve Drug Delivery for Cancer Therapy in Vitro and in Vivo. Nano Letters.2013, 13 (6): 2528–2534. 

2. Pilar Rivera_Gil, Dorleta Jimenez De Aberasturi, Verena Wulf, Beatriz Pelaz, Pablo Del Pino, Yuanyuan Zhao, Jesus De La Fuente, Idoia Ruiz De Larramendi, Teófilo Rojo, Xing-Jie Liang, Wolfgang J. Parak.The challenge to relate physico-chemical properties of colloidal nanoparticles to their cytotoxicity. Accounts of Chemical Research.2013.46(3):743-749. 

3. Shuaidong Huo, Huili Ma, Keyang Huang, Juan Liu, Tuo Wei, Shubin Jin, Jinchao Zhang, Shengtai He, and Xing-Jie Liang. Superior penetration and retention behavior of 50 nm gold nanoparticles in tumors. Cancer Research. 2013.73:319-330. 

4. Shubin Jin, Xiaowei Ma, Huili Ma, Kaiyuan Zheng, Juan Liu, Shuai Hou, Jie Meng, Paul C Wang, Xiaochun Wu, Xing-Jie Liang*.Surface Chemistry-Mediated Penetration and Gold Nanorods Thermotherapy in Multicellular Tumor Spheroids. Nanoscale.2013,5(1):143-146. 

5. Kumar A, Chen F, Mozhi A, Zhang X, Zhao Y, Xue X, Hao Y, Zhang X, Wang PC, Liang XJ*.Innovative pharmaceutical development based on unique properties of nanoscale delivery formulation. Nanoscale.2013 

6. Yuanyuan Zhao, Xu Zhang, Xiangdong Xue, Zhipeng Li, Fei Chen, Shengliang Li, Anil Kumar, Guozhang Zou*, and Xing-Jie Liang*.High Throughput Detection of Human Neutrophil Peptides from Serum, Saliva and Tear by Anthrax Lethal Factor-Modified Nanoparticles. ACS Applied Materials & Interfaces. 2013.5(17):8267-8272. 

7. Xue Xue, Matthew Hall, Qiang Zhang, Paul Wang, Michael M Gotteman, Xing-Jie Liang*.Nanoscale Drug Delivery Platforms Overcome Platinum-Based Resistance in Cancer Cells Due to Abnormal Membrane Protein Trafficking. ACS Nano. 2013.7(12):10452–10464 

8. Hua Deng, Xu Zhang, Anil Kumar, Guozang Zou , Xiaoning Zhang *and Xing-Jie Liang *.Long genomic DNA amplicons adsorption onto unmodified gold nanoparticles for colorimetric detection of Bacillus anthracis. Chemical Communication. 2013.49:51-53. 

9. Farzin Haque, Jinghong Li, Hai-Chen Wu, Xing-Jie Liang, and Peixuan Guo. Solid-state and biological nanopore for real-time sensing of single chemical and sequencing of DNA. Nano Today.2013. 8(1): 56-74. 

10. Beatriz Pelaz, Ga？lle Charron, Christian Pfeiffer, Yuliang Zhao, Jesus M. de la Fuente, Xing-Jie Liang, Wolfgang J. Parak, and Pablo del Pino*.Interfacing Engineered Nanoparticles with Biological Systems: Anticipating Adverse Nano-Bio Interactions. Small.2013 

11. Wendi Zhang, Qiang Cheng, Shutao Guo, Daoshu Lin, Pingsheng Huang, Juan Liu, Tuo Wei, Liandong Deng, Zicai Liang, Xingjie Liang, Anjie Dong. Gene transfection efficacy and biocompatibility of polycation/DNA complexes coated with enzyme degradable PEGylated hyaluronic acid. Biomaterials. 2013. 

12. Xixue Hu, Xiaohong Hao, Yan Wu, Jinchao Zhang, Xiaoning Zhang, Paul C Wang, Guozhang Zou, Xing-Jie Liang*. Multifunctional hybrid silica nanoparticles for controlled doxorubicin loading and release with thermal and pH dually response. J. Mater. Chem.2013. 1: 1109-1118 

13. Kangning Yang, Weipeng Cao, Xiaohong Hao, Xue Xue, Jing Zhao, Juan Liu, Yuliang Zhao, Jie Meng, Baoyun Sun, Jinchao Zhang, Xing-Jie Liang.* Metallofullerene Nanoparticles Promote Osteogenic Differentiation of Bone Marrow Stromal Cells through BMP Signaling Pathway. Nanoscale.2013. 5 (3), 1205 – 1212 

14. Qiang Cheng, Yuanyu Huang, Hua Zheng, Tuo Wei, Shuquan Zheng, Shuaidong Huo, Xiaoxia Wang, Quan Du, Xiaoning Zhang, Hong-Yan Zhang, Xing-Jie Liang, Chun Wang, Rupei Tang, Zicai Liang. The effect of Guanidinylation of PEGylated Poly(2-aminoethyl methacrylate) on the Systemic Delivery of siRNA. 15. Biomaterials.2013. 34(12):3120-3131 

15. Liming Hu, Yun Sun, Shengliang Li, Xiaoli Wang, Kelei Hu, Lirong Wang, Xing-jie Liang, Yan Wu.Multifunctional carbon dots with high quantum yield for imaging and gene delivery. Carbon. 2013.67:508-513. 　　  

2012年 

1. Lu Han, Jing Zhao, Xu Zhang, Weipeng Cao, Xixue Hua, Guozhang Zoua, Xianglin Duan, Xing-Jie Liang*.Enhanced siRNA Delivery and Silencing Gold Chitosan Nanosystem with Surface Charge-Reversal Polymer Assembly and Good Biocompatibility. ACS Nano. 2012,6(8):7340-7351. 

2. Keyang Huang, Huili Ma, Juan Liu, Shuaidong Huo, Anil Kumar, Tuo Wei, Xu Zhang, Shubin Jin, Yaling Gan, Paul C. Wang, Shengtai He, Xiaoning Zhang and Xing-Jie Liang*. Size-Dependent Localization and Penetration of Ultrasmall Gold Nanoparticles in Cancer Cells, Multicellular Spheroids, and Tumors in vivo. ACS Nano.2012,6(5):4483–4493. 

3. Lu Han, Li-Bo Du, Anil kumar, Hong-Ying Jia, Xing-Jie Liang, Qiu Tian, Guang-Jun Nie and Yang Liu. Inhibitory effects of trolox-encapsulated chitosan nanoparticles on tert-butylhydroperoxide induced RAW264.7 apoptosis. Biomaterials. 2012,33(33):8517-8528. 

4. Xiao-Dong Zhang, Di Wu, Xiu Shen, Jie Chen, Yuan-Ming Sun, Pei-Xun Liu, Xing-Jie Liang*.Size-dependent radiosensitization of PEG-coated gold nanoparticles for cancer. Biomaterials. 2012,33(27):6408-6419. 

5. Deng Hua, Xu Zhang, Guozang Zou, Anil Kumar, Xiaoning Zhang and Xing-Jie Liang*.Long genomic DNA amplicons adsorption onto unmodified gold nanoparticles for colorimetric detection of Bacillus anthracis. Chemical Communication.2012,49(1):51-53. 

6. Juan Liu, Huili Ma, Tuo Wei and Xing-Jie Liang*.CO2 gas induced drug release from pH-sensitive liposome to circumvent doxorubicin resistant cells. Chemical Communication. 2012,48:4869–4871. 

7. Yuran Huang, Sha He, Weipeng Cao, Kaiyong Cai and Xing-jie Liang*.Biomedical nanomaterials for imaging-guided cancer therapy. Nanoscale. 2012,4(20):6135 – 6149. 

8. LiRong Wang, LiHua Zhang, Xue Xue, Guanglu Ge and Xing-Jie Liang*.Enhanced dispersibility and cellular transmembrane capability of single-walled carbon nanotubes individualised by polycyclic organic compounds as chaperon. Nanoscale. 2012,4:3983-3989. 

9. Hua Deng, Yi Xu, Shuxian Shan, Yun Sun, Xiaofang Liu, Keyang Huang, Xiaowei Ma, Guozang Zou, Zhijun Che, Yanhua Liu, and Xing-Jie Liang*.Gold Nanoparticles with Asymmetric Polymerase Chain Reaction for Colorimetric Detection of DNA Sequence. Analytical Chemistry.2012,84(3):1253-1258. 

10. Xiaowei Ma, Huan Wang, Shubin Jin, Yan Wu*, Xing-Jie Liang *.Construction of paclitaxel-loaded poly(2-hydroxyethyl methacrylate)-g-poly (lactide)-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine copolymer nanoparticle delivery system and evaluation of its anticancer activity. International Journal of Nanomedicine. 2012,7:1313-1328. 

2011年 

1. Xiao-wei Ma, Yuliang, Zhao, Xing-Jie Liang*.Theranostic Nanoparticles engineered for Clinic and Pharmaceutics. Accounts of Chemical Research. 2011,44(10):1114-1122. 

2. Shutao Guo,Yuanyu Huang,Wendi Zhang,Weiwei Wang,Tuo Wei,Daoshu Lin, Jinfeng Xing,Liandong Deng,Quan Du,Zicai Liang*,Xing-Jie Liang*,Anjie Dong* .Ternary Complexes of Amphiphilic Polycaprolactone-graft-Poly (N,N-dimethylaminoethyl methacrylate), DNA and Polyglutamic-graft-Poly(ethylene glycol) for Gene Delivery. Biomaterials. 2011,32:4283-4292. 

3. Ma, Xiaowei; Wu, Yanyang; Jin, Shubin; Yu, Li; Xing-Jie Liang*.Gold Nanoparticles Induce Autophagosome Accumulation through Size-Dependent Nanoparticle Uptake and Lysosome Impairment. ACS Nano.2011,5(11):8629-8639. 

4. Anil Kumar, Huli Ma Xu Zhang, Keyang Huang, Shubin Jin, Juan Liu, Tuo Wei, Weipeng Cao, Xing-Jie Liang*.Gold Nanoparticles functionalized with Therapeutic and Targeted Peptides for Cancer Treatment. Biomaterials.2011,33:1180-1189. 

2010年 

1. Guo, S.T., Huang, Y., Wei, T., Wang, W.D., Wang, W.W., Lin, D., Zhang, X., Kumar, A., Du, Q., Xing, J., Deng, L., Liang, Z., Wang, P., Dong A., and Liang, X.J.* Amphiphilic and Biodegradable Methoxy Polyethylene glycol-block-(polycaprolactone-graft-poly (2-(dimethylamino)ethyl methacrylate)) as an Effective Gene Carrier. Biomaterials, 2010, 09.052. 

2. Meng, J., Wang, DL., Wang, PC., Jia, L., Chen, C, Liang, XJ*. Biomedical Activities of Endohedral Metallofullerene Optimized for Pharmaceutics. Journal of Nanoscience and Nanotechnology. 2010, 10: 8610-8616. 

3. 薛雪，游松，梁兴杰。肿瘤化疗耐药与其基因治疗药物的研究进展。中国药物化学杂志。2010，20（5）: 460-466 

4. Xue xue, You Song, Liang Xing-Jie. Chemotherapeutic resistance of cancer and its related gene therapeutic drugs. Chinese Journal of Medicinal Chemistry. 2010,20 (5): 460-466 

5. Guo, S.T., Huang, Y., Jiang, Q., Sun, Y., Deng, L., Liang, Z., Du, Q., Xing, J., Zhao, Y., Wang, P., Dong A., and Liang, X.J.*. Enhanced Gene Delivery and siRNA Silencing by Gold Nanoparticles Coated with Charge-reversal Polyelectrolyte. ACS Nano. 2010. 4(9): 5505-5511. 

6. Korotcov A, Shan L, Meng H, Wang TX, Sridhar R, Zhao YL, Liang XJ, Wang PC. A Nanocomplex System as Targeted Contrast Agent Delivery Vehicle for Magnetic Resonance Imaging Dynamic Contrast Enhancement Study. Journal of Nanoscience and Nanotechnology. 2010, 10: 7545-7549. 

7. Ma, X., Che, Z., Liu, Y., Guo, T. and Liang, X.J*. Application of Electrophoresis in the Separation of Nanoparticles. Science in China: C. 2010. 40 (10): 1478-1486. 

8. Guo, S.T, Qiao, Y., Wang, W., He, H., Deng, L., Xing, J., Xu, J., Liang, X.J., and Dong A. Poly(ε-caprolactone)-graft-poly(2-(N, N-dimethylamino) ethyl methacrylate) Nanoparticles: pH Dependent Thermo-Sensitive Multifunctional Carriers for Gene and Drug Delivery. Journal of Materials Chemistry, 2010, 6935-6941. 

9. Wang, Y., LV, J., Ma, X., Wang, D., Ma, H., Chang, Y., Nie, G., Jia, L., Duan, X. and Liang, X.J*. Specific hemosiderin deposition in spleen induced by a low dose of cisplatin: altered iron metabolism and its implication as an acute hemosiderin formation model. Current Drug Metabolism, 2010, 11: 507-515. 

10. Liang, X.J. *, Meng, H., Wang, Y., He, H., Meng, J., Lu, J., Wang, P. C., Zhao, Y., Gao, X., Sun, B., Chen, C., Xing, G., Shen, D., Gottesman, M. M., Wu, Y., Yin, J.J., Jia, L. Metallofullerene Nanoparticles Circumvent Tumor Resistance to Cisplatin by Reactivating Endocytosis. PNAS 2010. 107(16):7449-7454. 

11. Ma, H., Wang, P C, Qian, F. and Liang, X.J*. Biological Effects of Nanomaterials and Drugs Measured by the Small-animal SPECT/CT Imaging System IN VIVO. Acta Biophysica Sinica. 2010. 26(8): 691-701. 

12. Meng, H., Xing, G., Sun, B., Zhao, F., Lei, H., Li, W., Song, Y., Chen, Z., Yuan, H., Xia, W., Jing, L., Chen, C., Liang, X.J., Zhang, N.,Chai, Z, Zhao, Y. Potent angiogenesis inhibition by particulate form of fullerene Derivatives. ACS Nano 2010, 25; 4(5):2773-83. 

13. Ma, X.W., Wang, D., Wu, Y., Ho, RJY, Jia, L., Guo, P., Hu, L., Xing, G., Zeng, Y., Liang, X.J*. AIDS Treatment with Novel Anti-HIV Compounds Improved by Nanotechnology. AAPS J. 2010, 12(3):272-278. 

14. Xing, J, Deng, L, Guo, S, Dong, A, and Liang, X.J*. Polycationic Nanoparticles as Nonviral Vectors Employed for Gene Therapy In Vivo. Mini-Reviews in Medicinal Chemistry. 2010, 10(2):126-37. 

15. Tan, J.J., Cong, X.J., Hu, L.M., Wang, C.X., Jia, L and Liang, X.J*. Therapeutic Strategies Underpinning the Development of Novel Techniques for the Treatment of HIV Infection. Drug Discovery Today. 2010. 15(5): 186-197. 

2009年 

1. Jia, L., Zhao, Y. and Liang, X.J. Current Evaluation of the Millennium Phytomedicine--Ginseng (II): Collected Chemical Entities, Modern Pharmacology, and Clinical Applications Emanated from Traditional Chinese Medicine. Current Medicinal Chemistry, 2009, 16, 2924-2942. 

2. Wang, P.C., Blumenthal, R.P., Zhao, Y, Schneider, J.A., Miller, N., Grodzinski, P., Gottesman, M.M., Tinkle, S., Wang, K., Wang, C., Liang, X.J*. Building Scientific Progress without Borders: Nanobiology and Nanomedicine in China and the U.S. Cancer Research. 2009, 69: 5294-5295.  

3. Wang, Y.Z., Huang, B., Lv J., and Liang XJ*. Current Status Of Nanotechnology Applied In Biomedicine. Acta Biophysica Sinica 2009, 25(3): 168-174. 

4. Wan, L.X., Liang, XJ and Huang YG. Characterization of the ATPase activity of a novel chimeric protein consisting of two nucleotide binding domains of MRP1. Archives of Biochemistry and Biophysics. 2009, 485(2):102-108. 

5. Wang YZ， Duan XL，Li YF，Liang XJ*. Multidrug Resistance Mediated by Half ABC Transporter ABCG2. Prog. Biochem. Biophys, 2009, 36(12): 1523-1529. 

6. Yin, JJ., Lao, F., Fu, PP., Wamer WG., Zhao, YL, Wang, PC., Qiu, Y., Sun, B, Xing G, Dong, J., Liang, XJ*, Chen, C. The scavenging of reactive oxygen species and the potential for cell protection by functionalized fullerene materials. Biomaterials. 2009, 30(4):611-621 * 

2008年 

1. Wang,P.C, Shan, L., Wang, S.P., Korotcov, A and Liang, XJ. Transferrin Liposome Nanoparticle (TfNIR-LipNBD-Magnevist) – A Tumor Targeting MRI Contrast Agent. Acta Biophysica Sinica. 2008, 24(4):315-322. 

2. Liang, X.J. *, Chen, C.Y., Zhao, Y.L., Jia, L., Wang, PC. Biopharmaceutics and Therapeutic Potential of Engineered Nanomaterials. Current Drug Metabolism. 2008, Oct; 9(8):697-709, 

3. Yin, JJ., Lao, F., Meng, J., Fu, PP., Zhao, YL, Xing G, Gao X, Sun, B, Wang, PC., Chen, C, Liang, XJ*. Inhibition of Tumor Growth by Polyhydroxylated Endohedral Metallofullerenol Nanoparticles Optimized as Reactive Oxygen Species Scavenger. Molecular Pharmacology. 2008, 74: 1132-1140. 

4. Liang, X. J.*, Shen, D.W., Yin, J.J., Aszalos, A., and Gottesman, M. M. SIRT1 contributes to cisplatin resistance in cancer cells by altering mitochondrial metabolism. Molecular Cancer Research. 2008, 6(9):1499-1506. 

5. Liang, X.J., Choi, Y., Sackett, D.L. and Park, J.K. Inhibition of stathmin enhances CCNU blocking glioma cell migration and invasion. Cancer Research. 2008, 68(13):5267-5272. 

6. Gao, X, Xing G, Chu, W, Liang, X.J., Zhao, Y, Jing, L., Yuan, H, Cui, Y, Dong J. The Growth of Complex Nanostructures: Synergism of Dipolar Force and Stacking-Defect in Anisotropic Self-assembly, Advanced Materials. 2008, 20, 1794–1798. 

7. Liang, X.J.,Yin, J.J., Taylorc, B, Wincovitch S M., Garfield, S., Shen D.W., Gottesman, M.M. and　 Aszalose A. Disruption of microfilaments by cytochalasin B decreases accumulation of cisplatin in human epidermal carcinoma and liver carcinoma cell lines. Cancer Chemotherapy and Pharmacology. 2008, 62(6):977-84. 

8. Hall MD, Okabe M, Shen, DW, Liang, XJ, and Gottesman, MM. The Role of Cellular Accumulation in Determining Sensitivity to Platinum-Based Chemotherapy*. Annual Review of Pharmacology and Toxicology. 2008，48: 495-535. 

9. Wu WW, Wang G, Liang XJ, Park JK, Shen RF. Covalent modification of stathmin by CCNU determined by FTMS analysis of modified proteins and tryptic peptides. Biochem Biophys Res Commun. 2008; 367(1):7-13. 

2007年及以前 

1. Ngo.T.B*, Peng T., *, Liang X.J *., Akeju O., Pastorino S., Zhang W., Fine H.A., Maric D., Wen P.Y., Girolami U.D., Black P.M., Wu W., Shen R.F., Kang D.W., and Park J.K. The 1p encoded protein stathmin modulates the response of malignant gliomas to nitrosoureas. Journal of National Cancer Institute. 2007, 99: 639-652. [*: Equal contribution] 

2. Liang, X. J. and Aszalos A. Multidrug transporters as drug targets. Current Drug Targets. 2006, 7 (8): Aug 911-921. 

3. Liang, X. J., Mukherjee, S., Shen, D. W., Maxfield, F. R. and Gottesman, M. M. Endocytic Recycling Compartments Altered in Cisplatin-Resistant Cancer Cells . Cancer Research. 2006, 66 (4): Feb 15; 2346-2353. 

4. Liang, X. J., Taylor B, Cardelli C, Yin JJ, Annereau JP, Garfield SH, Wincovitch S, Szakacs G, Gottesman, M. M and Aszalos A. Different roles for K+ channels in cisplatin resistant cell lines Argue Against a Critical Role for These Channels in Cisplatin Resistance. Anticancer Research. 2005, 25(6B): 4113-4122. 

5. Liang, X. J., Shen, D. W., Chen G. K., Wincovitch S. M., Garfield, S., and Gottesman, M. M. Trafficking and localization of platinum complexes in cisplatin-resistant cell lines monitored by fluorescence-labeled platinum. Journal of Cellular Physiology. 2005, 202 (3): 635-641. 

6. Liang, X.J, Shen, D.W, and Gottesman, M.M. Down-regulation and altered localization of g-catenin in cisplatin-resistant adenocarcinoma cells. Molecular Pharmacology. 2004 65 (5): 1217-1224. 

7. Liang, X.J, Shen, D.W, and Gottesman, M.M. A pleiotropic defect reducing drug accumulation in cisplatin-resistant cells. Journal of Inorganic Biochemistry. 2004 (98) 1599-1606. 

8. Liang, X.J, Yin, J.J., Zhou, J.W., Wang, P. C., Taylor, B., Cardarelli, C., Kozar, M, Forte, R., Aszalos, A.and Gottesman, M. M.: Changes in biophysical parameters of plasma membranes influence cisplatin resistance of sensitive and resistant epidermal carcinoma cells. Experimental Cell Research. 2004, 293: 283-291. 

9. Liang, X. J., Shen, D. W., Garfield, S., and Gottesman, M. M. Mislocalization of membrane proteins associated with multidrug resistance in cisplatin-resistanct cancer cell lines. Cancer Research. 2003, 63: 5909-5916.  

Book Chapters: 

1. Gottesman, M.M., Hall, M.D., Liang, X.J., and Shen, D.W.: Resistance to Cisplatin Results from Multiple Mechanisms in Cancer Cells. In Bonetti, A. Leone, R. Muggia, F. Howell, S.B. (Eds.): Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy: Molecular Mechanisms and Clinical Applications. Humana Press, Totowa, New Jersey, 2009, 83-88. 

2. Liang, X.J., Chen, C.Y., Zhao, Y.L., Wang, P.C. Circumventing tumor resistance to chemotherapy by nanotechnology. Multi-Drug Resistance in Cancer Series: Methods in Molecular Biology , Zhou, Jun (Ed.), Humana Publisher, New York, 2010; 596: 467-488 

　　Zhang C, Xue X, Luo Q, Li Y, Yang K, Zhuang X, Jiang Y, Zhang J, Liu J, Zou G, Liang XJ. Self-assembled Peptide nanofibers designed as biological enzymes for catalyzing ester hydrolysis. ACS Nano. 2014. 8(11):11715-23. 

　　Zhang C, Xue X, Luo Q, Li Y, Yang K, Zhuang X, Jiang Y, Zhang J, Liu J, Zou G, Liang XJ. Self-assembled Peptide nanofibers designed as biological enzymes for catalyzing ester hydrolysis. ACS Nano. 2014. 8(11):11715-23. 

　　Zhang C, Xue X, Luo Q, Li Y, Yang K, Zhuang X, Jiang Y, Zhang J, Liu J, Zou G, Liang XJ. Self-assembled Peptide nanofibers designed as biological enzymes for catalyzing ester hydrolysis. ACS Nano. 2014. 8(11):11715-23.