人才队伍

姓名:	杨延莲	性别:	女
职务:	无	职称:	研究员
通讯地址:	北京市海淀区中关村北一条11号
邮政编码:	100190	电子邮件:	yangyl(AT)nanoctr.cn

简历：

杨延莲，博士，国家纳米科学中心研究员。1992年9月至1999年7月在山东大学化学学院进行大学本科和硕士研究生学习，1999年9月至2002年6月于北京大学化学与分子工程学院攻读博士学位，之后继续从事博士后研究两年。2004年7月至今，被聘为国家纳米科学中心副研究员和研究员，2007年10月-2008年11月到美国麻省理工学院生物医学工程中心做访问学者。2014年9月联合创办北京中科纳泰生物科技有限公司，任公司首席科学家。

主要研究兴趣包括：基于多肽纳米结构的液体活检技术、多肽组装结构及其调控的分子机制、多肽纳米药物、基于扫描探针显微技术的纳米表征方法等。主持和参与多项国家级研究项目，如国家重大科学研究计划课题负责人、国家重点研发专项课题负责人、中科院战略性先导科技专项A类项目子课题负责人等。在Chem. Soc. Rev., Nat. Comm., Proc. Natl. Acad. Sci. USA, Adv. Mater., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Nano Lett., ACS Nano, Nano Today等知名学术期刊发表论文200余篇，他引4000多次，H因子35。

研究领域：
	1. 基于多肽纳米结构的液体活检技术 2. 多肽组装结构及其调控的分子机制 3. 多肽纳米药物 4. 基于扫描探针显微技术的纳米表征方法杨延莲课题组网站：http://www.nanoctr.cas.cn/yangyanliangroup/

社会任职：

获奖及荣誉：

代表论著：

1. Qing You, Kaiyue Zhang, Jingyi Liu, Changliang Liu, Huayi Wang, Mengting Wang, Siyuan Ye, Houqian Gao, Letian Lv, Chen Wang, Ling Zhu,* and Yanlian Yang*, Persistent Regulation of Tumor Hypoxia Microenvironment via a Bioinspired Pt-Based Oxygen Nanogenerator for Multimodal Imaging-Guided Synergistic Phototherapy, Adv. Sci., 2020, 7, 1903341,DOI: 10.1002/advs.201903341.

2. Huiwen Du, Xiaoyu Hu, Hongyang Duan, Lanlan Yu, Fuyang Qu, Qunxing Huang, Wangshu Zheng, Hanyi Xie, Jiaxi Peng, Rui Tuo, Dan Yu, Yuchen Lin, Wenzhe Li, Yongfang Zheng, Xiaocui Fang, Yimin Zou, Huayi Wang, Mengting Wang, Paul S. Weiss*, Yanlian Yang*, Chen Wang*, “Principles of Inter-Amino-Acid Recognition Revealed by Binding Energies between Homogeneous Oligopeptides” ACS Central Science, 2019, 5(1), 97-108 DOI: 10.1021/acscentsci.8b00723 (封面文章)

3. Yongfang Zheng, Lanlan Yu, Yimin Zou, Yanlian Yang*, Chen Wang* “Steric Dependence of Chirality Effect in Surface-Mediated Peptide Assemblies Identified with Scanning Tunneling Microscopy”, Nano Letters, 2019, 19(8), 5403-5409, DOI: 10.1021/acs.nanolett.9b01904，12.

4. Wenzhe Li, Huayi Wang, Zijian Zhao, Houqian Gao, Changliang Liu, Ling Zhu,*Chen Wang,* and Yanlian Yang* “Emerging Nanotechnologies for Liquid Biopsy: The Detection of Circulating Tumor Cells and Extracellular Vesicles”, Advanced Materials, 2018,1805344; DOI: 10.1002/adma.201805344 (封面文章)

5. Yumin Chen, Ke Deng*, Shengbin Lei, Rong Yang, Tong Li , Yuantong Gu, Yanlian Yang*, Xiaohui Qiu* ,Chen Wang*, “Single-molecule insights into surface-mediated homochirality in hierarchical peptide assembly”, Nature Communications, 2018, 9(1): 2711;DOI: 10.1038/s41467-018-05218-0

6. Wenzhe Li, Bin Shao, Changliang Liu, Huayi Wang, Wangshu Zheng, Weiyao Kong, Xiaoran Liu, Guobin Xu, Chen Wang, Huiping Li,* Ling Zhu,* and Yanlian Yang*, “Noninvasive Diagnosis and Molecular Phenotyping of Breast Cancer through Microbead-Assisted Flow Cytometry Detection of Tumor-Derived Extracellular Vesicles” Small Methods, 2018, 2(11), 1800122; DOI: 10.1002/smtd.201800122 (封面文章)

7. Ling Zhu, Zijian Zhao, Peng Cheng, Zhaohui He, Zhiqiang Cheng, Jiaxi Peng, Huayi Wang, Chen Wang,* Yanlian Yang,* and Zhiyuan Hu*, “Antibody-Mimetic Peptoid Nanosheet for Label-Free Serum-Based Diagnosis of Alzheimer’s Disease”, Adv. Mater. 2017, 29, doi.org/10.1002/adma.201700057.

8. Niu, Lin¹; Liu, Lei¹; Xi, Wenhui¹; (Equal contribution) Li, Qiang; Han, Qiusen; Yu, Yue; Huang, Qunxing; Qu, Fuyang; Xu, Meng; Li, Yibao; Du, Huiwen; Yang, Rong; Cramer, Jacob; Gothelf, Kurt; Dong, Mingdong; Besenbacher, Flemming; Zeng, Qingdao; Wang, Chen*; Wei, Guanghong*; Yang, Yanlian*, “Synergistic inhibitory effect of Peptide-Organic Co-assemblies on Amyloid Aggregation”, ACS Nano, 2016, 10 (4), pp 4143–4153.

9. Lei Liu^？, Lin Niu^？, (Equal contribution) Meng Xu, Qiusen Han, Hongyang Duan, Mingdong Dong, Flemming Besenbacher, Chen Wang*, Yanlian Yang*, “Molecular tethering effect of C-terminus of amyloid peptide Aβ42”, ACS Nano, 2014, 8(9), 9503-9510.

10. Shelley A. Claridge, Jeffrey J. Schwartz, Miles A. Silverman, John C. Thomas, Yanlian Yang,* Chen Wang,* and Paul S. Weiss*, “Differentiating Amino Acid Residues and Side Chain Orientations in Peptides Using Scanning Tunneling Microscopy” J. Am. Chem. Soc. 2013,135(49), 18528–18535.

11. Xiaobo Mao¹, Yuanyuan Guo¹, Yin Luo¹, (Equal contribution) Lin Niu, Lei Liu, Xiaojing Ma, Huibin Wang, Yanlian Yang*, Guanghong Wei*, Chen Wang*, “Sequence Effects on Peptide Assembly Characteristics Observed by Using Scanning Tunneling Microscopy” J. Am. Chem. Soc. 2013, 135 (6), 2181–2187.

12. Min Zhang, Xiaobo Mao, Yue Yu, Chenxuan Wang, Xiaobo Mao, Yanlian Yang,* Chen Wang* “Nanomaterials for reducing amyloid cytotoxicity”, Adv. Mater.,2013, DOI: 10.1002/adma.201301210.

13. Min Zhang¹, Xiaobo Mao¹, (Equal contribution) Chenxuan Wang, Wenfeng Zeng, Chunling Zhang, Zhongjun Li, Ying Fang, Yanlian Yang,* Wei Liang*, Chen Wang*, “The Effect of Graphene oxide on Conformation Change, Aggregation and Cytotoxicity of HIV-1 Regulatory Protein (Vpr)”, Biomaterials, 2013, 34(4), 1383-1390.

14. Xiaobo Mao, Chenxuan Wang, Xingkui Wu, Xiaojing Ma, Lei Liu, Lan Zhang, Lin Niu, Yuanyuan Guo, Denghua Li, Yanlian Yang*, Chen Wang*, “Beta structure motifs of islet amyloid polypeptides identified through surface-mediated assemblies” Proc. Natl. Acad. Sci. USA. 2011, 108(49), 19605-19610.

15. Lei Liu^#, Lan Zhang^#(Co-first authors), Lin Niu, Meng Xu, Xiaobo Mao, Yanlian Yang*, Chen Wang*, “Observation of Reduced Cytotoxicity of Aggregated Amyloidogenic Peptides with Chaperone-like Molecules” ACS Nano, 2011, 5(7), 6001-6007.

16. Yanlian Yang, Chen Wang*, Hierarchical construction of self-assembled low-dimensional molecular architectures observed by using scanning tunneling microscopy, Chem. Soc. Rev., 2009, 38, 2576-2589.

17. Lei Liu, Lan Zhang, Xiaobo Mao, Lin Niu, Yanlian Yang,* and Chen Wang* “Chaperon-Mediated Single Molecular Approach Toward Modulating Ab Peptide Aggregation” Nano Lett., 2009, 9(12), 4066-4072.

18. Yanlian Yang, Ulung Khoe, Xiumei Wang, Akihiro Horii, Hidenori Yokoi and Shuguang Zhang* “Designer Self-assembling Peptide Nanomaterials”, Nano Today, 2009, 4, 193-210.

19. Yanlian Yang, Qilin Chan, Xiaojing Ma, Yongtao Shen, Ke Deng, Xizeng Feng*, Chen Wang*, Electrical Conformational Bistability of Dimesogen Molecules with a Molecular Chord Structure”, Angew. Chem. Int. Ed., 2006, 45, 6889-6893.

20. 纳米科技创新方法研究，王琛，杨延莲等编著，科学出版社：北京，2012.2.

承担科研项目情况：

1. 中国科学院战略性先导科技专项（A类）：变革性纳米产业制造技术聚焦；项目3：纳米结构在特定能源、环境与健康领域中的应用；课题3：药物创制和体外诊断中的纳米技术；子课题6：恶性肿瘤体外诊断XDA09030306，2013.7.1-2017.12.31，子课题负责人。

2. 国家重点研发计划：科研实验室认可关键技术研究，课题三：科研实验室纳米尺度特性量值测量能力验证技术研究，2016YFF0203803，2016.07.01- 2019.06.30，课题负责人。

3. 北京市科委计划项目先导与优势材料创新发展：多肽-纳米磁珠材料中试工艺研究，Z171100002017013，2017/01-2018/12，课题负责人，300万元。

4. 国家自然科学基金委面上项目21273051：基于特异性识别多肽的循环肿瘤细胞检测新方法研究，2013.1-2016.12，已结题，项目负责人。

5. 国家自然科学基金委面上项目21773042多肽纳米聚集体的分子调控及其抗肿瘤效应研究，2018.1-2021.12，项目负责人。

6. 中国科学院战略性先导科技专项（B类）:功能纳米系统的精准构筑原理与测量，项目2：功能纳米系统的精确表征与测量，课题3：纳米-生物界面精准测量，2020.01-2024.12，参与。