人才队伍

姓名:	陈春英	性别:	女
职务:	无	职称:	研究员
通讯地址:	北京市海淀区中关村北一条11号
邮政编码:	100190	电子邮件:	chenchy(AT)nanoctr.cn

简历：

　　陈春英，中国科学院院士，国家纳米科学中心研究员、博士生导师，新基石研究员。国家杰出青年科学基金获得者，中国科学院纳米生物效应与安全性重点实验室副主任，先后担任国家重点研发计划“纳米科技”重点专项、“纳米前沿”重点专项首席科学家。

　　1996年在华中科技大学获得博士学位，之后在中科院高能物理研究所、瑞典卡罗林斯卡大学诺贝尔医学生物化学研究所从事博士后研究工作。2002年在中科院高能所纳米生物效应与安全实验室，任课题组长。2006年6月加入国家纳米科学中心。先后主持科技部国家重点研发计划“纳米科技”重点专项和“纳米前沿”重点专项、国家自然科学基金委国家重大科研仪器研制项目、国家自然科学基金委重大研究计划重点支持项目、欧盟第六、第七框架计划(EU-FP6&FP7)、欧盟“地平线2020”计划、德国联邦教育与研究部合作项目、丹麦战略研究委员会项目、丹麦科技与创新局项目、国际原子能机构协调研究计划(IAEA)等多项国内与国际合作项目。

　　先后当选中国化学会会士、美国医学与生物工程院会士、英国皇家化学会会士。应邀担任著名国际组织ISO、WHO和OECD的专家。被Nature Nanotechnology评价为该领域Leading Scientist(引领科学家)，并被Nature人物专访。担任ACS Nano执行主编以及 Science Bulletin, Bioconjugate Chemistry, Engineering, Metallomics, Nano Today, Nanoscale Horizons, Nanoscale, Nanotoxicology, Particle and Fibre Toxicology和Current Drug Metabolism等多个期刊的编委或顾问编委等。

　　两次荣获“国家自然科学二等奖(2018年排名第一，2012年排名第二)”；2019年作为纳米生物效应与安全性研究集体的“突出贡献者”获“中国科学院杰出科技成就奖”；2023年获“IUPAC化学化工杰出女性奖”；2022年获“中国科学院大学领雁奖”；2021年获“中国科学院优秀导师奖”，“全国五一巾帼标兵”，英国皇家化学会“Environment Prize”，美国化学会“Bioconjugate Chemistry讲座奖”；2020年获“发展中国家科学院TWAS化学奖”(2022年颁奖)；2019年获得“中国毒理学杰出贡献奖”；2018、2017、2014年分别入选Clarivate Analytics公布的“全球高引用科学家”；2017年获中科院第五届“十大杰出妇女”；2014年获第十一届“中国青年女科学家奖”，入选“国家百千万人才工程”，获得“有突出贡献中青年专家”称号；2011年被评为“中国标准化杰出人物-创新人物”；2008年获“北京市科学技术进步奖二等奖(第二获奖人)”。

　　目前主要从事纳米蛋白冠的分析方法及其化学生物学效应、纳米材料生物体内行为的检测方法与机制、纳米佐剂与递送系统研究。研究成果在Nature Nanotechnology、Nature Methods、Nature Communications、PNAS、JACS、Angew Chem等国际学术期刊发表SCI论文390余篇，有37篇入选ESI-TOP 1%高被引论文，研究成果被引用>4.3万次，H-Index为109(Google学术)。2019年应邀为Nature Nanotechnology撰写Nanomedicine领域Correspondence文章，评述纳米生物医学研究方法学进展。中国授权发明专利45项，国际授权PCT发明专利1项（美国、欧盟、日本）。主编中英文专著8部，分别由英国RSC、德国Wiley、科学出版社和冶金工业出版社出版。

研究领域：
	纳米蛋白冠的分析方法及其化学生物学效应；纳米材料生物体内行为的检测方法与机制；纳米佐剂与递送系统。　　中文主页：http://www.nanoctr.cas.cn/chenchunying/ketizu 英文主页：http://english.nanoctr.cas.cn/chenchunying/home

社会任职：

获奖及荣誉：

代表论著：

1. Mingjing Cao, Yaling Wang, Liming Wang, Kai Zhang, Yong Guan, Yuecong Guo, Chunying Chen*. In situ label-free X-ray imaging for visualizing the interaction of nanomedicine with subcellular architecture in intact single cells. Nature Protocols, 2024, 19: 30-59. pdf

2. Zhiguo Fang, Chenlei Wang, Jingrun Yang, Zhizheng Song, Chunyu Xie, Yu Ji, Zhongliang Wang, Xiaohui Du, Qiang Zheng, Chunying Chen*, Zhiyuan Hu*, Yeteng Zhong*. Oxyhaemoglobin saturation NIR-IIb imaging for assessing cancer metabolism and predicting the response to immunotherapy. Nature Nanotechnology, 2024, 19: 124-130. pdf

3. Guofang Zhang, Yalin Cong, Feng-Liang Liu, Jiufeng Sun, Jiantian Zhang, Guoli Cao, Lingqiang Zhou, Wenjie Yang, Qingle Song, Fangjun Wang, Ke Liu, Jing Qu, Jing Wang, Min He, Shun Feng, Didar Baimanov, Wei Xu, Rong-Hua Luo, Xin-Yan Long, Shumin Liao, Yunping Fan, Yu-Feng Li, Bai Li, Ximing Shao, Guocheng Wang, Lijing Fang, Huaiyu Wang, Xue-Feng Yu, Yan-Zhong Chang, Yuliang Zhao, Liang Li, Peng Yu, Yong-Tang Zheng*, Diana Boraschi, Hongchang Li*, Chunying Chen*, Liming Wang*, Yang Li*. A Nanomaterial Targeting the Spike Protein Captures SARS-CoV-2 Variants and Promotes Viral Elimination. Nature Nanotechnology, 2022, 17: 993-1003. pdf

4. Mingjing Cao, Rong Cai, Lina Zhao, Mengyu Guo, Liming Wang, Yucai Wang, Lili Zhang, Xiaofeng Wang, Haodong Yao, Chunyu Xie, Yalin Cong, Yong Guan, Xiayu Tao, Yaling Wang, Shaoxin Xu, Ying Liu, Yuliang Zhao, Chunying Chen*. Molybdenum Derived from Nanomaterials Incorporates into Molybdenum Enzymes and Affects Their Activities in vivo. Nature Nanotechnology, 2021, 16: 708-716. pdf

5. Xuefei Lu, Yong Zhu, Ru Bai, Zhengsheng Wu, Wenchang Qian, Leiyan Yang, Rong Cai, Hong Yan, Tao Li, Vijay Pandey, Ying Liu, Peter E. Lobie, Chunying Chen*, Tao Zhu*. Long-term Pulmonary Exposure to Multi-walled Carbon Nanotubes Promotes Breast Cancer Metastatic Cascades. Nature Nanotechnology, 2019, 14(7): 719-727. pdf (Highlighted by Nature Nanotechnology, 2019, 14: 639-640. pdf)

6. Didar Baimanov, Jing Wang, Jun Zhang, Ke Liu, Yalin Cong, Xiaomeng Shi, Xiaohui Zhang, Yufeng Li, Xiumin Li, Rongrong Qiao, Yuliang Zhao, Yunlong Zhou*, Liming Wang*, Chunying Chen*. In Situ Analysis of Nanoparticle Soft Corona and Dynamic Evolution. Nature Communications, 2022, 13: 5389. pdf

7. Qiwei Wang, Ying Liu, HuiWang, Penglei Jiang, Wenchang Qian, Min You, Yingli Han, Xin Zeng, Jinxin Li, Huan Lu, Lingli Jiang, Meng Zhu, Shilin Li, Kang Huang, Mingmin Tang, Xinlian Wang, Liang Yan, Zecheng Xiong, Xinghua Shi, Ge Bai, Huibiao Liu, Yuliang Li, Yuliang Zhao, Chunying Chen*, Pengxu Qian*. Graphdiyne Oxide Nanosheets Display Selective Anti-leukemia Efficacy Against DNMT3A-mutant AML Cells. Nature Communications, 2022, 13: 5657. pdf

8. Xiaoyu Wang, Xuejing Cui*, Junguang Wu, Lin Bao, Zhiqiang Tan, Chunying Chen*. Peripheral nerves directly mediate the transneuronal translocation of silver nanomaterials from the gut to central nervous system. Science Advances, 2023, 9(27): eadg2252. pdf

9. Xuejing Cui, Xiaoyu Wang, Xueling Chang, Lin Bao, Junguang Wu, Zhiqiang Tan, Jinmei Chen, Jiayang Li, Xingfa Gao, Pu Chun Ke, Chunying Chen*. A new capacity of gut microbiota: Fermentation of engineered inorganic carbon nanomaterials into endogenous organic metabolites. PNAS, 2023, 120(20): e2218739120. pdf (Highlighted by Nature, 2023, 617: 441. pdf)

10. Yalin Cong, Rongrong Qiao, Xiaofeng Wang, Yinglu Ji, Jiacheng Yang, Didar Baimanov, Shengtao Yu, Rui Cai, Yuliang Zhao, Xiaochun Wu*, Chunying Chen*, Liming Wang*. Protein Corona-Mediated Inhibition of Nanozyme Activity: Impact of Protein Shape. JACS, 2024, 146(15): 10478-10488. pdf

11. Longwei Wang, Xiaodi Zhang, Zhen You, Zhongwei Yang, Mengyu Guo, Jiawei Guo, He Liu, Xiaoyu Zhang, Zhuo Wang, Aizhu Wang, Yawei Lv*, Jian Zhang, Xin Yu*, Jing Liu*, Chunying Chen*. A Molybdenum Disulfide Nanozyme with Charge-Enhanced Activity for Ultrasound-Mediated Cascade-Catalytic Tumor Ferroptosis. Angewandte Chemie International Edition, 2023, 135(11): e202301206. pdf

12. Rong Cai, Jiayu Ren, Mengyu Guo, Taotao Wei, Ying Liu, Chunyu Xie, Peng Zhang, Zhiling Guo, Andrew J. Chetwynd, Pu Chun Ke, Iseult Lynch, Chunying Chen*. Dynamic Intracellular Exchange of Nanomaterials’ Protein Corona Perturbs Proteostasis and Remodels Cell Metabolism. PNAS, 2022, 119: e2200363119. pdf

13. Shuangfei Cai*, Jiaming Liu, Jianwei Ding, Zhao Fu, Haolin Li, Youlin Xiong, Zheng Lian, Rong Yang*, Chunying Chen*. Tumor-Microenvironment-Responsive Cascade Reactions by a Cobalt-Single-Atom Nanozyme for Synergistic Nanocatalytic Chemotherapy. Angewandte Chemie International Edition, 2022, e202204502. pdf

14. Jiaming Liu, Aizhu Wang, Shihui Liu, Ruiqi Yang, Longwei Wang, Fene Gao, Huige Zhou, Xin Yu*, Jing Liu*, Chunying Chen*. A Titanium Nitride Nanozyme for pH-Responsive and Irradiation-Enhanced Cascade-Catalytic Tumor Therapy. Angewandte Chemie International Edition, 2021,60(48): 25328-25338.pdf

15. Huige Zhou, Mengyu Guo, Jiayang Li, Fenglan Qin, Yuqing Wang, Tao Liu, Jing Liu, Zeinab Farhadi Sabet, Yaling Wang, Ying Liu, Qing Huo, Chunying Chen*. Hypoxia-Triggered Self-Assembly of Ultrasmall Iron Oxide Nanoparticles to Amplify the Imaging Signal of a Tumor. Journal of the American Chemical Society, 2021, 143(4): 1846-1853. pdf

16. Yang Cai, Dongqi Ni, Wenyu Cheng, Chendong Ji, Yaling Wang, Klaus Müllen, Zhiqiang Su*, Ying Liu, Chunying Chen*, Meizhen Yin*. Enzyme-Triggered Disassembly of Perylene Monoimide-based Nanoclusters for Activatable and Deep Photodynamic Therapy. Angewandte Chemie International Edition, 2020, 59(33): 14014-14018. pdf

17. Jiayang Li, Kejian Shi, Zeinab Farhadi Sabet, Wenjiao Fu, Huige Zhou, Shaoxin Xu, Tao Liu, Min You, Mingjing Cao, Mengzhen Xu, Xuejing Cui, Bin Hu, Ying Liu, Chunying Chen*. New Power of Self-assembling Carbonic Anhydrase Inhibitor: Short Peptide-constructed Nanofibers Inspire Hypoxic Cancer Therapy. Science Advances, 2019, 5(9): eaax0937. pdf

18. Yaling Wang, Rong Cai, Chunying Chen*. The Nano-Bio Interactions of Nanomedicines: Understanding the Biochemical Driving Forces and Redox Reactions. Accounts of Chemical Research, 2019, 52: 1507-1518. pdf

19. Ge Fang, Weifeng Li, Xiaomei Shen, Jose Manuel Perez-Aguilar, Yu Chong, Xingfa Gao, Zhifang Chai, Chunying Chen*, Cuicui Ge*, Ruhong Zhou*. Differential Pd-nanocrystal Facets Demonstrate Distinct Antibacterial Activity Against Gram-positive and Gram-negative Bacteria. Nature Communications, 2018, 9: 129. pdf

20. Liming Wang, Qiang Sun, Xin Wang, Tao Wen, Junjie Yin, Pengyang Wang, Ru Bai, Xiang-Qian Zhang, Lu-Hua Zhang, An-Hui Lu*,Chunying Chen*. Using Hollow Carbon Nanospheres as a Light-induced Free Radical Generator to Overcome Chemotherapy Resistance. Journal of the American Chemical Society, 2015, 137(5): 1947-1955. pdf

21. Liming Wang, Jingyuan Li, Jun Pan, Xiumei Jiang, Yinglu Ji, Yufeng Li, Ying Qu, Yuliang Zhao, Xiaochun Wu*, Chunying Chen*. Revealing the Binding Structure of the Protein Corona on Gold Nanorods Using Synchrotron Radiation-Based Techniques: Understanding the Reduced Damage in Cell Membranes. Journal of the American Chemical Society, 2013, 135: 17359-17368. pdf

22. Ying Liu, Yuliang Zhao, Baoyun Sun*, Chunying Chen*. Understanding the Toxicity of Carbon Nanotubes. Accounts of Chemical Research, 2013, 46 (3): 702-713.pdf

承担科研项目情况：