人才队伍

姓名:	李素萍	性别:	女
职务:	无	职称:	研究员
通讯地址:	北京市海淀区中关村北一条11号
邮政编码:	100190	电子邮件:	lisuping@nanoctr.cn

简历：

李素萍，研究员，博士生导师。2015-2017年先后于美国约翰霍普金斯大学医学院和麻省理工学院（MIT）访学合作。研究成果以第一或通讯作者（含共同）发表在Nature Biotechnology, Nature Materials, Nature Biomedical Engineering, Cell Reports Medicine, Nature Reviews Cancer, Nature Communications等期刊；实现专利转化5项（其中1项正在招募患者开展临床试验）。成果入选2018年中国科学十大进展，入选美国The Scientist 2018 “Top Technical Advances”，入选“十三五”科技创新成果展；荣获北京市自然科学奖一等奖（第二完成人），中国药学会科学技术二等奖（第四完成人）等。荣获中国工程院“中国工程前沿杰出青年学者”。主持国家重点研发计划、基金委重大研究计划、中科院创新交叉团队项目等。入选国家级青年人才、北京市杰青。

研究领域：
	1）靶向调控肿瘤血管微环境成分（血小板、凝血因子等）的智能纳米药物设计、构建及其效应研究； 2）靶向溶栓、止血微纳药物的研发。

社会任职：

获奖及荣誉：

代表论著：

1. Xin Zeng^#, Zhenzhu Wang^#, An Zhao^{#, *}, Yiqi Wu^#, Zongping Wang, Aiwen Wu, Qing Wang, Xin Xia, Xichen Chen, Wene Zhao, Bozhao Li, Zefang Lu, Qiaoli Lv, Guorong Li, Zhixiang Zuo, Fengrui Wu, Yuliang Zhao, Ting Wang^*, Guangjun Nie^*, Suping Li^*, Gen Zhang^*. Zinc nanoparticles from oral supplements accumulate in renal tumours and stimulate antitumour immune responses. Nature Materials. 2025, 24(2): 287-296.

2. Suying Wu^#, Zhouliang Wu^#, Zefang Lu, Feilong Qi, Jin Cheng, Tianjiao Chu, Bozhao Li, Yuliang Zhao, Guangjun Nie, Suping Li^*. Selective apoptosis of tumor-associated platelets boosts the anti-metastatic potency of PD-1 blockade therapy. Cell Reports Medicine. 2025, 6: 101984.

3. Suping Li^#,*, Zefang Lu^#, Suying Wu, Tianjiao Chu, Bozhao Li, Feilong Qi, Yuliang Zhao, Guangjun Nie^*. The dynamic role of platelets in cancer progression and their therapeutic implications. Nature Reviews Cancer. 2024, 24(1): 72-87.

4. Yuan Liang^#, Yunkai Qie^#, Jing Yang, Ranfeng Wu, Shuang Cui, Yuliang Zhao, Greg J. Anderson, Guangjun Nie, Suping Li^*, Cheng Zhang^*. Programming conformational cooperativity to regulate allosteric protein-oligonucleotide signal transduction. Nature Communications. 2023, 14(1): 4898.

5. Bozhao Li^#, Feilong Qi^#, Fei Zhu^#, Zefang Lu, Meiqi Wang, Tianjiao Chu, Suying Wu, Jingyan Wei, Zhenchuan Song, Saraswati Sukumar, Cheng Zhang, Jiangfei Xu, Suping Li^*, Guangjun Nie^*. Nanoparticle-based combination therapy enhances fulvestrant efficacy and overcomes tumor resistance in ER-positive breast cancer. Cancer Research. 2023, 83(17): 2924-2937.

6. Bozhao Li^#, Zefang Lu^#, Zhenlin Yang^#, Xiuping Zhang, Meiqi Wang, Tianjiao Chu, Peina Wang, Feilong Qi, Greg J Anderson, Ershuai Jiang, Zhenchuan Song, Guangjun Nie^*, Suping Li^*. Monitoring circulating platelet activity to predict cancer-associated thrombosis. Cell Reports Methods. 2023, 3(7): 100513.

7. Suping Li^#, Yinlong Zhang^#, Shih-Hsin Ho, Bozhao Li, Meifang Wang, Xiongwei Deng, Na Yang, Guangna Liu, Zefang Lu, Junchao Xu, Quanwei Shi, Jing-Yan Han, Lirong Zhang, Yan Wu^*, Yuliang Zhao^*, Guangjun Nie^*. Combination of tumour-infarction therapy and chemotherapy via the co-delivery of doxorubicin and thrombin encapsulated in tumour-targeted nanoparticles. Nature Biomedical Engineering. 2020, 4(7): 732-742.

8. Xin Zeng^#, Jie Sun^#, Suping Li^#, Jiyun Shi^#, Han Gao, Wei Sun Leong, Yiqi Wu, Minghui Li, Chengxin Liu, Ping Li, Jing Kong, Yi-Zhou Wu^*, Guangjun Nie^*, Yuming Fu^*, Gen Zhang^*. Blood-triggered generation of platinum nanoparticle functions as an anti-cancer agent. Nature Communications. 2020, 11(1): 567.

9. Suping Li^#, Qiao Jiang^#, Shaoli Liu^#, Yinlong Zhang^#, Yanhua Tian, Chen Song, Jing Wang, Yiguo Zou, Gregory J Anderson, Jing-Yan Han, Yung Chang, Yan Liu, Chen Zhang, Liang Chen, Guangbiao Zhou, Guangjun Nie^*, Hao Yan^*, Baoquan Ding^*, Yuliang Zhao^*. A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo. Nature Biotechnology. 2018, 36(3): 258-264.

10. Suping Li^#, Yinlong Zhang^#, Jing Wang^#, Ying Zhao, Tianjiao Ji, Xiao Zhao, Yanping Ding, Xiaozheng Zhao, Ruifang Zhao, Feng Li, Xiao Yang, Shaoli Liu, Zhaofei Liu, Jianhao Lai, Andrew K. Whittaker, Gregory J. Anderson, Jingyan Wei, Guangjun Nie^*. Nanoparticle-mediated local depletion of tumour-associated platelets disrupts vascular barriers and augments drug accumulation in tumours. Nature Biomedical Engineering. 2017, 1(8): 667-679.

承担科研项目情况：