人才队伍

姓名:	李一叶	性别:	女
职务:	无	职称:	研究员
通讯地址:	北京市海淀区中关村北一条11号
邮政编码:	100190	电子邮件:	liyy@nanoctr.cn

简历：

李一叶，研究员，博士生导师。2008年毕业于中国医学科学院基础医学研究所医学分子生物学国家重点实验室，获理学博士学位；同年在国家纳米科学中心从事博士后研究；2011年加入国家纳米科学中心工作。长期从事智能纳米体系的药物递送及纳米生物效应研究，关注胰腺癌的纳米诊疗。近年发表研究论文30余篇，其中第一/通讯作者论文发表于Nature Reviews Materials，Nature Communications，Advanced Materials，Journal of the American Chemical Society，Angewandte Chemie International Edition，ACS NANO，National Science Review等国际学术期刊，部分研究成果被Nature Materials等学术期刊推荐为研究亮点。

研究领域：
	肿瘤纳米生物学,纳米生物效应

社会任职：

获奖及荣誉：

代表论著：

2018年以来代表性论文：

1. Jing Wang^#, Yiye Li^#, Guangjun Nie*, Multifunctional Biomolecule Nanostructures for Cancer Therapy. Nature Reviews Materials, 2021, DOI: 10.1038/s41578-021-00315-x.

2. Huan Min, Yingqiu Qi, Yinlong Zhang, Xuexiang Han, Keman Cheng, Ying Liu, Hiubiao Liu, Jianshe Hu*, Guangjun Nie*, Yiye Li*, A Graphdiyne Oxide-Based Iron Sponge with Photothermally-Enhanced Tumor-Specific Fenton Chemistry, Advanced Materials, 2020, 32(31): e2000038.

3. Xuexiang Han, Keman Cheng, Ying Xu, Yazhou Wang, Huan Min, Yinlong Zhang, Xiao Zhao, Ruifang Zhao, Gregory J. Adnderson, Lei Ren, Guangjun Nie*, Yiye Li*, Modularly Designed Peptide Nanoprodrug Augments Anti-Tumor Immunity of PD-L1 Checkpoint Blockade by Targeting Indoleamine 2, 3-Dioxygenase, Journal of the American Chemical Society, 2020, 142, 2490-2496.

4. Xuexiang Han, Ying Xu, Marzieh Geranpayehvagheia, Gregory J. Anderson, Yiye Li*, Guangjun Nie*, Emerging Nanomedicines for Anti-Stromal Therapy Against Desmoplastic Tumors, Biomaterials, 2020, 232, 119745.

5. Huan Min, Jing Wang, Yingqiu Qi, Yinlong Zhang*, Xuexiang Han, Ying Xu, Junchao Xu, Yao Li, Long Chen, Keman Cheng, Guangna Liu, Na Yang, Yiye Li*, Guangjun Nie*, Biomimetic Metal-Organic Framework Nanoparticles for Cooperative Combination of Antiangiogenesis and Photodynamic Therapy for Enhanced Efficacy, Advanced Materials, 2019, 31(15):e1808200.

6. Xuexiang Han, Ying Xu, Yiye Li*, Xiao Zhao, Yinlong Zhang, Huan Min, Yingqiu Qi, Gregory J. Anderson, Linhao You, Yuliang Zhao*, Guangjun Nie*, An Extendable Star-like Nanoplatform for Functional and Anatomical Imaging-Guided Photothermal Oncotherapy, ACS NANO, 2019, 13(4): 4379-4391.

7. Ying Xu, Xuexiang Han, Yiye Li*, Huan Min, Xiao Zhao, Yinlong Zhang, Yingqiu Qi, Jian Shi, Sheng Qi, Yongping Bao*, Guangjun Nie*, Sulforaphane Mediates Glutathione Depletion via Polymeric Nanoparticles to Restore Cisplatin Chemosensitivity, ACS NANO, 2019, 13(11), 13445？13455.

8. Xuexiang Han, Yiye Li*, Ying Xu, Xiao Zhao, Yinlong Zhang, Xiao Yang, Yongwei Wang, Ruifang Zhao, Greg J Anderson, Yuliang Zhao*, Guangjun Nie*, Reversal of Pancreatic Desmoplasia by Re-Educating Stellate Cells with a Tumour Microenvironment-Activated Nanosystem, Nature Communications, 2018, 9 (1):3390.

9. Yiye Li, Jing Wang, Feng Zhao, Bing Bai, Guangjun Nie, André E Nel*, Yuliang Zhao*, Nanomaterial Libraries and Model Organisms for Rapid High Content Analysis of Nanosafety, National Science Review, 2018, 5(3): 365–388

承担科研项目情况：