郑文富，国家纳米科学中心研究员。2008年7月毕业于北京大学，获得理学博士学位，专业为生物物理学，主要从事单分子纳米生物医学研究；同年加入国家纳米科学中心从事博士后研究；2010年留所至今，历任助理研究员、副研究员、项目研究员和研究员。

近年来以纳米材料和微流控芯片为基本研究工具和实现手段，构建了多种器官芯片，发展了多种纳米药物载体及纳米药物，为肿瘤、脑疾病、心血管、感染等重大疾病的防治提供了新技术和新策略；已经发表SCI论文80余篇，论文被引用超2900次（Web of Science检索）；已申请国家发明专利45项，其中授权11项；作为负责人的项目经费约1820万，负责和参与的项目经费总额约2200万；受邀作为Nano Today、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Small、Nano Lett.、Nanoscale、Adv. Sci.、 Biomaterials、ACS Appl. Mater. Interfaces等杂志审稿人。目前主要从事纳米抗菌材料的转移转化及产业化探索。

(1)器官芯片； 

(2)纳米药物载体及递送； 

(3)纳米抗菌材料产业化。 

1. Xiaoyan Liu, Yuexiao Jia, Ziwei Han, Qinghong Hou, Wei Zhang*, Wenfu Zheng*, Xingyu Jiang*, Integrating a concentration gradient generator and a single-cell trapper array for high-throughput screening the bioeffects of nanomaterials, Angew. Chem. Int. Ed., 60, 12319 (2021).

2. Le Wang, Junchuan Yang, Sixiang Li, Qizhen Li, Shaoqin Liu*, Wenfu Zheng*, Xingyu Jiang*, Oral administration of starting materials for in vivo synthesis of antibacterial gold nanoparticles for curing remote infections, Nano Lett., 21, 2, 1124 (2021).

3. Xiaoyan Liu, Wei Zhang*, Wenfu Zheng*, Xingyu Jiang*, Micropatterned coculture platform for screening nerve-related anticancer drugs, ACS Nano., 15, 637 (2021).

4. Yangzhouyun Xie, Junchuang Yang, Jiangjiang Zhang, Wenfu Zheng*, Xingyu Jiang*, activating antibacterial effect of 4,6-diamino-2-pyrimidinethiol-modified gold nanoparticles by reducing their sizes, Angew. Chem. Int. Ed., 59, 23471 (2020).

5. Le Wang, Sixiang Li, Jiaxiang Yin, Junchuan Yang, Qizhen Li, Wenfu Zheng*, Shaoqin Liu*, Xingyu Jiang*, The density of surface coating can contribute to different antibacterial activities of gold nanoparticles, Nano Lett., 20, 5036 (2020).

6. Ying Li, Rongbing Tang, Xiaoyan Liu, Junyi Gong, Zujin Zhao, Zonghai Sheng, Jiangjiang Zhang, Xuanyu Li, Guangle Niu, Ryan T. K. Kwok, Wenfu Zheng*, Xingyu Jiang*, and Ben Zhong Tang*, Bright aggregation-induced emission nanoparticles for two-photon imaging and localized compound therapy of cancers, ACS Nano., 14, 16840 (2020).

7. Sixiang Li, Le Wang, Wenfu Zheng*, Guang Yang*, Xingyu Jiang*, Rapid fabrication of self-healing, conductive, and injectable gel as dressings for healing wounds in stretchable parts of the body, Adv. Funct. Mater., 30, 2002370 (2020).

8. Jun Li, Chun-Lin Sun, Pengrong An, Xiaoyan Liu, Ruihua Dong, Jinghong Sun, Xingyu Zhang, Yanbo Xie, Chuanguang Qin, Wenfu Zheng*, Haoli Zhang*, Xingyu Jiang*, Construction of dopamine-releasing gold surfaces mimicking presynaptic membrane by on-chip electrochemistry, J. Am. Chem. Soc., 141, 8816 (2019).

9. Lingmin Zhang, Le Wang, Yangzhouyun Xie, Peng Wang, Sai Deng, Aiping Qin, Jiangjiang Zhang, Xiyong Yu*, Wenfu Zheng*, Xingyu Jiang*, Triple-targeting delivery of CRISPR/Cas9 to reduce the risk of cardiovascular diseases, Angew. Chem. Int. Ed., 58, 12404 (2019). (Hot paper)

10. Wenfu Zheng, Xingyu Jiang*, Synthesizing living tissues with microfluidics, Acc. Chem. Res., 51, 3166 (2018). (封面)

11. Peng Wang, Lingmin Zhang, Wenfu Zheng*, Liman Cong, Zhaorong Guo, Yangzhouyun Xie, Le Wang, Rongbing Tang, Qiang Feng, Yoh Hamada, Kohsuke Gonda, Zhijian Hu, Xiaochun Wu, Xingyu Jiang*, Thermo-triggered release of CRISPR-Cas9 system by lipid-encapsulated gold nanoparticles for tumor therapy, Angew. Chem. Int. Ed., 57, 1491 (2018). (Hot paper)

12. Ying Li, Zheng Zhao, Jiangjiang Zhang, Ryan T. K. Kwok, Sheng, Xie, Rongbing Tang, Yuexiao Jia, Junchuan Yang, Le Wang, Jacky W. Y. Lam, Wenfu Zheng*, Xingyu Jiang*, Ben Zhong Tang*, A bifunctional aggregation-induced emission luminogen for monitoring and killing of multidrug-resistant bacteria, Adv. Funct. Mater.,1804632 (2018).

13. Junchuan Yang, Le Wang, Wei Zhang, Zhen Sun, Ying Li, Mingzhu Yang, Di Zeng, Baogan Peng, Wenfu Zheng*, Xingyu Jiang*, Guang Yang*, Reverse reconstruction and bioprinting of bacterial cellulose-based functional total intervertebral disc for therapeutic implantation, Small, 13, 1702582 (2018).

14. Lingmin Zhang, Ying Li, Qinghua Chen, Yong Xia, Wenfu Zheng*, Xingyu Jiang*, The construction of drug-resistant cancer cell lines by CRISPR/Cas9 system for drug screening, Sci. Bull., 63, 1411 (2018).

15. Yifeng Lei, Lixue Tang, Yangzhouyun Xie, Yunlei Xianyu, Lingmin Zhang, Peng Wang, Yoh Hamada, Kai Jiang, Wenfu Zheng*, Xingyu Jiang*, Gold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer, Nat. Commun., 8, 15130 (2017).

16. Shiyu Cheng, Yu Jin, Nuoxin Wang, Feng Cao, Wei Zhang, Wei Bai*, Wenfu Zheng*, Xingyu Jiang*, Self-adjusting, polymeric multilayered roll that can keep the shapes of the blood vessel scaffolds during biodegradation, Adv. Mater., 29, 1700171 (2017).

17. Peng Wang, Lingmin Zhang, Yangzhouyun Xie, Nuoxin Wang, Rongbing Tang, Wenfu Zheng*, Xingyu Jiang*, Delivery of Cas9 protein/sgRNA plasmid for genome editing and cancer therapy by gold nanocluster/lipid core-shell nanocarrier, Adv. Sci., 4, 1700175 (2017).  

18. Ying Li, Yue Tian, Wenshu Zheng, Yan Feng, Rong Huang, Jingxin Shao, Rongbing Tang, Peng Wang, Yuexiao Jia, Jiangjiang Zhang, Wenfu Zheng*, Guang Yang*, Xingyu Jiang*, Composites of bacterial cellulose and small molecule-decorated gold nanoparticles for treating Gram-negative bacteria-infected wounds, Small, 13, 1700130 (2017).

19. Wenfu Zheng, Rong Huang, Bo Jiang, Yuyun Zhao, Wei Zhang, Xingyu Jiang*, An early-stage atherosclerosis research model based on microfluidics, Small, 15, 2022 (2016). (封面)

20. Yifeng Lei, Yoh Hamada, Jun Li, Liman Cong, Nuoxin Wang, Ying Li, Wenfu Zheng*,  Xingyu Jiang*, Targeted tumor delivery and controlled release of neuronal drugs with ferritin nanoparticles to regulate pancreatic cancer progression. J. Control. Release, 232, 131 (2016).

21. Zhuo Huang, Yi Sun, Wenwen Liu, Wei Zhang, Wenfu Zheng*, Xingyu Jiang*, Assembly of functional three-dimensional neuronal networks on a microchip, Small, 10, 2530 (2014). (内封面)